We aimed to evaluate the effects of carnitine-orotate complex in patients with nonalcoholic fatty liver disease (NAFLD) and diabetes.
Effective medicines have not been introduced for insulin resistance related fatty liver. We compared the efficacy and safety of treatment between a combination of metformin and carnitine-orotate complex and metformin alone in a 12-week, double-blind, randomized, placebo-controlled study on drug-naive patients with impaired glucose metabolism and fatty liver.
Carnitine and vitamin complex (Godex®) is widely used in patients with chronic liver disease who show elevated liver enzyme in South Korea. The purpose of this study is to identify the efficacy and safety of carnitine from entecavir combination therapy in Alanine aminotransferase (ALT) elevated Chronic Hepatitis B (CHB) patients.
Godex is a multicomponent drug that contains Carnitine Orotate, 17 amino acids, Adenine hydrochloride, and Vitamins B2, B6, B12,), which has hepatoprotective activity. This study evaluated the effect of Godex on biochemical items associated with liver function and hepatitis B virus DNA level to patients with chronic hepatitis, fatty liver and liver cirrhosis.
GODEX is a multicomponent drug that contains Carnitine Orotate, 17 amino acids, Adenine hydrochloride, and Vitamins B2, B6, B12, which has been used for managing chronic liver diseases in Korea and other countries. The purpose of this study was to evaluate the efficacy and safety of GODEX in Korean patients with chronic liver disease.
Non-alcoholic steatohepatitis (NASH) is a known metabolic disorder of the liver. No treatment has been conclusively shown to improve NASH or prevent disease progression. The function of L-carnitine to modulate lipid profile, glucose metabolism, oxidative stress, and inflammatory responses has been shown. The aim of this study was to evaluate the effects of L-carnitine's supplementation on regression of NASH.
Functional and anatomical abnormalities of mitochondria play an important role in developing steatohepatitis. Carnitine is essential for enhanced mitochondrial beta oxidation through the transfer of long-chain fatty acids into the mitochondria. We examined the impact of carnitine orotate (GODEX) on liver function and peripheral blood mitochondria copy number in NAFLD patients.