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ABSTRACT

OBJECTIVE

To observe the therapeutic effect of Carnitine-orotate on gastric ulcer and discuss the relevant mechanism.

METHODS

HE dyeing observation was applied into the rat gastric healing process.Elisa test IL-8,IL-10 expression. Immunohistochemical method was applied to test the expression of EGF.

RESULTS

• Carnitine-orotate can heal gastric ulcer.
• Carnitine-orotate can reduce MDA content of the organization,Strengthen SOD,Through anti-oxidation stress treatment ulcers.
• Carnitine-orotate inhibit inflammatory factor IL-8,10 expression and play a role in anti- oxidation.
• Carnitine-orotate resistance and promote EGF.

CONCLUSIONS

Carnitine-orotate is effective to treat stomach ulcers mainly through anti-oxidation stresses and promote the expression of EGF.

KEYWORDS

Carnitine-orotate gastric ulcer antioxidant stress growth factor rats

FUND

辽宁省教育厅重点实验室项目 编号:2009506

CATEGORY INDEX

R965

DOI

CNKI:SUN:JZYX.0.2010-01-008