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Authors and Disclosures

Tae-woo Yu1, Byung-ik Kim1, Young-oh Kweon2, Joung-il Lee3, Byung-hun Han4, Mong Cho5, Seong-gyu Hwang6, Yun-soo Kim7, Chae-yoon Chon8, Seung-ok Lee9, Byung-cheol Song10, Byung-seok Lee11, Ju-huun Sohn12

Kor J Clin Pharmacol Ther Vol. 9, No. 2, 2001

Sungkyunkwan University School of Medicine Seoul1, Kyungpook National University College of Medicine Daegu2, Kyung Hee University College of Medicine Seoul3, Kosin University Gospel Hospital Busan4, Pusan National University College of Medicine Busan5, Bun Dan CHA University College of Medicine Sungnam6, Soon Chun Hyang University College of Medicine Seoul7, Yonsei University College of Medicine Seoul8, Chonbuk National University College of Medicine Chonju9, Cheju National University College of Medicine Cheju10, Chungnam National University College of Medicine Daejeon11, Hanyang University College of Medicine Seoul12

ABSTRACT

Godex is a multicomponent drug that contains Carnitine Orotate, 17 amino acids, Adenine hydrochloride, and Vitamins B2, B6, B12,), which has hepatoprotective activity. This study evaluated the effect of Godex on biochemical items associated with liver function and hepatitis B virus DNA level to patients with chronic hepatitis, fatty liver and liver cirrhosis. A total of 242 patients with chronic hepatitis, fatty liver and liver cirrhosis who visited to 12 medical centers from Nov. 2002 to Feb. 2005 and have no other medicines except it were enrolled in this study. We retrospectively evaluated the changes of biochemical items such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, albumin, prothrombin time, platelet count and hepatitis B virus DNA level before and at 1, 3, 6, 9 and 12 months after the Godex treatment. In patients with chronic hepatitis, ALT and total bilirubin have shown statistically significant changes (p < 0.05). In patients with fatty liver and liver cirrhosis, the ALT level alone was significantly changed (p < 0.05). Otherwise, hepatitis B virus DNA level was not changed. Even if some biochemical items were improved in patients with chronic hepatitis, fatty liver and hepatic cirrhosis after Godex treatment, it did not affect the change of hepatitis B virus DNA level.